ASSESSMENT OF C-REACTIVE PROTEIN AND PROCALCITONIN IN POSTMORTEM DIAGNOSIS OF SEPSIS
Loading...
Authors
Caravaca, April
Issue Date
2013
Type
Thesis
Language
en
Keywords
Alternative Title
Abstract
The intention of this project was to examine the stability and suitability of C-reactive protein and procalcitonin as chemical biomarkers in the diagnosis of postmortem sepsis. This study was inspired by the high mortality rates of sepsis in the intensive care unit and the difficulty of sepsis diagnosis both clinically antemortem and in postmortem fatalities. C-reactive protein in femoral blood is stable postmortem (< 0.0002, p-value of C-reactive protein in relationship to postmortem interval time where p < 0.05 is significant), whereas procalcitonin must be used with discretion (0.2345 - 0.66825, 0.2345 - 0.6825, p-value of procalcitonin Lenora. blood and pericardial fluid where p < 0.05 is significant. This investigation suggests that C-reactive protein and procalcitonin have no significant difference and thus both biomarkers are analogous in the discrimination of sepsis related fatalities (0.884, p-value of sensitivity and specificity comparison of C-reactive protein and procalcitonin where p< 0.05 is’ significant).